Which of the following is NOT a class of potassium-sparing diuretics?

Potassium-sparing diuretics are a specific category of diuretics that help to maintain potassium levels in the body while promoting diuresis. The two main classes of potassium-sparing diuretics are Na-channel inhibitors and aldosterone antagonists.

Na-channel inhibitors, such as amiloride and triamterene, work by blocking sodium channels in the distal nephron of the kidney, which enhances sodium excretion while retaining potassium. Aldosterone antagonists, such as spironolactone and eplerenone, inhibit the action of aldosterone, a hormone that promotes sodium retention and potassium excretion. By blocking aldosterone's effects, these agents help preserve potassium levels.

In contrast, thiazides and loop diuretics do not belong to the potassium-sparing category. Thiazides, like hydrochlorothiazide, and loop diuretics, such as furosemide, are known to cause potassium loss rather than retention. They promote diuresis primarily through mechanisms that do not spare potassium, which is why they are not classified as potassium-sparing diuretics.

Thus, identifying thiazides as not a class of potassium-sparing diuretics is accurate, as they actively lead to increased