Which of the following is a common side effect of ACE inhibitors?

A persistent dry cough is indeed a common side effect associated with ACE inhibitors. This occurs due to the accumulation of bradykinin, a peptide that can increase with ACE inhibition. Normally, ACE (angiotensin-converting enzyme) helps regulate blood pressure by converting angiotensin I to angiotensin II and breaking down bradykinin. When ACE is inhibited, bradykinin levels rise, leading to increased activity in the respiratory tract that can trigger a cough reflex, which often manifests as a persistent, dry cough.

In contrast, while skin rash, weight gain, and insomnia can occur with certain medications, they are not primarily associated with ACE inhibitors. Skin rash is more commonly linked to other classes of medication or can occur due to hypersensitivity reactions. Weight gain is typically not a direct side effect of ACE inhibitors; some antihypertensive drugs can cause weight gain due to fluid retention, but ACE inhibitors usually help reduce blood pressure without affecting weight. Insomnia is also not directly related to the use of ACE inhibitors; in fact, these medications aim to improve heart function and reduce cardiovascular stress, potentially leading to better overall health and even improved sleep quality for some patients.