Which drug is representative of Central α2-agonists?

Clonidine is a representative of central α2-agonists, which are a class of medications used to treat hypertension by acting on the central nervous system. These drugs work primarily by stimulating alpha-2 adrenergic receptors in the brain, which leads to reduced sympathetic outflow. This physiological response lowers blood pressure by decreasing heart rate and dilating blood vessels, making it a useful option for managing high blood pressure.

The other choices represent different classes of antihypertensive agents. Atenolol is a beta-blocker that primarily works by blocking beta-adrenergic receptors, thus reducing heart rate and contractility. Lisinopril is an ACE inhibitor that decreases the production of angiotensin II, a potent vasoconstrictor, helping to relax blood vessels and lower blood pressure. Amlodipine is a calcium channel blocker that works by inhibiting calcium entry into vascular smooth muscle and cardiac muscle, helping to cause vasodilation and reduce blood pressure.

Each of these drugs acts on different pathways and receptors in the body, making clonidine distinct as a central α2-agonist specifically targeting the central nervous system to manage hypertension.