Which class of antihypertensives can be safely taken with NSAIDs?

Calcium channel blockers are considered safe to take with NSAIDs because they do not interfere with the renal effects that can be caused by NSAIDs. Unlike other classes of antihypertensive agents, such as diuretics and certain types of beta-blockers and angiotensin receptor blockers, calcium channel blockers have a different mechanism of action. They work by inhibiting the entry of calcium into cardiac and smooth muscle cells, which leads to vasodilation and decreased blood pressure.

This mechanism does not significantly impact renal blood flow or sodium retention, issues that can arise when NSAIDs are used concurrently with other antihypertensive medications. Therefore, patients requiring pain relief from NSAIDs while managing hypertension can generally do so safely when their treatment includes calcium channel blockers.