Which class of agents is commonly associated with coughs and burning sensations?

The association of coughs and burning sensations with a specific class of antihypertensive agents is primarily linked to ACE inhibitors. ACE inhibitors work by blocking the angiotensin-converting enzyme, which leads to decreased production of angiotensin II. This reduction causes vasodilation and lowers blood pressure. However, a notable side effect of ACE inhibitors is the accumulation of bradykinin, which is thought to cause the dry cough often reported by patients.

The burning sensation can occur due to various reasons, including tissue irritation resulting from the ongoing action of bradykinin or other mediators. The cough associated with ACE inhibitors is significant enough that it may cause some patients to discontinue their use of the medication altogether.

In contrast, other classes like angiotensin receptor blockers typically do not produce a cough because they do not influence bradykinin levels in the same way. Beta-blockers and diuretics also have different side effect profiles, with neither commonly causing coughs or burning sensations. This distinctive side effect of ACE inhibitors is a key clinical consideration when prescribing antihypertensive agents.