What is the rationale for using calcium channel blockers as the drug of choice for systolic hypertension?

Calcium channel blockers are particularly effective in managing systolic hypertension primarily because of their ability to vasodilate rigid arteries. Systolic hypertension is characterized by elevated systolic blood pressure, often resulting from increased stiffness of the arterial walls. The mechanism of action for calcium channel blockers involves the relaxation of vascular smooth muscle. By blocking calcium entry into cells of the vascular wall, these medications promote dilation of the arteries, which decreases vascular resistance and helps lower blood pressure.

When the arteries are more dilated, it leads to a reduction in the amount of pressure exerted against arterial walls during systole, thereby bringing down systolic blood pressure effectively. This is especially beneficial in older patients, who typically present with more rigid arteries. Additionally, the improved arterial compliance contributes to overall cardiovascular health and reduces the risk of complications associated with prolonged high blood pressure.

Other options do not directly address the primary mechanism by which calcium channel blockers effectively manage systolic hypertension. For instance, while some diuretics may inhibit sodium reabsorption, this is not the action of calcium channel blockers. Reducing heart rate can occur as part of the overall response to calcium channel blockers, but it is not their primary role in hypertension management. Similarly, this class of drugs does not inherently