What is a common side effect that may cause patients to avoid taking ACE inhibitors?

The correct answer is dry cough, which is a well-documented and common side effect associated with the use of ACE inhibitors. This class of medications works by inhibiting the angiotensin-converting enzyme, which plays a crucial role in the renin-angiotensin-aldosterone system. While these medications are effective at managing hypertension and heart failure, they can lead to the accumulation of bradykinin, a substance that can cause irritation and subsequently result in a persistent, dry cough.

This side effect can be bothersome enough that some patients may discontinue their use of ACE inhibitors despite the benefits these medications offer for cardiovascular health. In clinical practice, the occurrence of a dry cough due to ACE inhibitors is significant enough that healthcare providers often discuss this potential side effect when prescribing them, and alternative antihypertensive options are considered if the cough develops.

The other side effects listed are less commonly associated with ACE inhibitors. For instance, while dizziness can occur due to various reasons related to blood pressure changes, it is not specific to ACE inhibitors. Similarly, constipation and rash are less frequently reported compared to the dry cough experienced by ACE inhibitor users.