What is a common side effect of α1 antagonists?

A common side effect of α1 antagonists is dizziness. These medications, which primarily act by blocking the α1 adrenergic receptors on smooth muscle, lead to vasodilation and a subsequent drop in blood pressure. This rapid reduction in blood pressure can result in postural hypotension, especially when a person stands up quickly or after sitting for extended periods. The sudden change in blood pressure may cause lightheadedness or dizziness, as the body adjusts to maintain adequate blood flow to the brain. This side effect is particularly important for patients to be aware of, as it can increase the risk of falls or accidents.

Other side effects, such as dry mouth, weight gain, or headaches, are less commonly associated with α1 antagonists and are not typically expected as major side effects of this class of medication. While patients may experience these symptoms, they are not the hallmark side effects linked to the pharmacological action of α1 antagonists.