What is a common side effect of ACE inhibitors?

ACE inhibitors, or Angiotensin-Converting Enzyme inhibitors, are a class of medications commonly used to treat hypertension and heart failure. Among their various side effects, a persistent cough is a well-documented and common adverse reaction. This occurs due to the accumulation of bradykinin, a peptide that is normally broken down by angiotensin-converting enzyme. When ACE is inhibited, bradykinin levels rise, which can lead to irritation of the respiratory tract and subsequent coughing.

It's important to note that while other side effects such as headaches can also occur with ACE inhibitors, they are not as characteristic as the cough. Weight gain is not typically associated with these medications, and in fact, they may promote weight loss in patients with heart failure due to improved fluid status. Constipation is generally not a common issue related to ACE inhibitors. Thus, the cough stands out as a key side effect, making it a classic response to these agents.