If a patient needs to take NSAIDs, which class of antihypertensive is generally preferred?

In the context of a patient needing to take nonsteroidal anti-inflammatory drugs (NSAIDs), calcium channel blockers are generally preferred due to their pharmacological profile and safety profile in this situation.

Calcium channel blockers work by preventing calcium from entering the cells of the heart and blood vessel walls, leading to relaxation of the blood vessels, decreased heart rate, and ultimately lowered blood pressure. They are not known to significantly affect renal function, unlike other antihypertensive classes such as ACE inhibitors or diuretics. This characteristic is especially relevant when NSAIDs are used, as NSAIDs can adversely impact kidney function and exacerbate hypertension by promoting sodium and water retention.

Choosing a calcium channel blocker can help manage hypertension without the added risk of NSAID-induced kidney complications that can arise with other antihypertensives. Hence, in scenarios where a patient requires NSAIDs, calcium channel blockers represent a safer option as they are less likely to interact negatively with the NSAIDs in terms of renal effects and blood pressure stability.